I. Patient Avatars
Representative models
Patient Avatars are animals that most closely represent human patients with our target indications and that have often acquired the disease naturally.
Gene therapy is fulfilling the promise of miracle cures for rare diseases. But even as delivery technology continues to mature, the field has yet to make headway for much more common complex diseases because of target risk. At Gordian, we leverage proven gene therapy delivery technology to screen thousands of targets for these diseases, eliminating this barrier.
II. Mosaic Screening
Pooled in vivo experiments
We create a pooled library of hundreds of therapies and test them in vivo in individual Patient Avatars.
At Gordian we embrace intentionality, intensity, and innovation as we pursue transformative therapies for complex diseases of aging. We set bold goals, take extreme ownership of outcomes, and challenge convention to deliver excellence in all that we do. Every Gor is empowered to communicate clearly, learn continuously, and drive impactful results that push our mission forward. Together, we leverage our collective strengths to make a tangible difference for patients.
III. Pythia
AI-Powered Analysis
Instead of focusing on a single hypothesis for disease, Gordian’s Pythia examines the entire transcriptome to see how each of these therapies affects dozens of cellular pathways in the living animal.
Learn more about our science
Recorded Gordian conference talks
- Biology of Aging 2024
- Single-Cell Biology: Tissue Genomics, Technologies and Disease
- American Society For Gene & Cell Therapy Annual Meeting 2023
- Aging Research & Drug Discovery 2021
- Aging Research & Drug Discovery 2020
- American Society For Gene & Cell Therapy Annual Meeting 2020
- International Conference On Machine Learning 2019