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I. Patient Avatars

Representative models

Patient Avatars are animals that most closely represent human patients with our target indications and that have often acquired the disease naturally.

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Gene therapy is fulfilling the promise of miracle cures for rare diseases. But even as delivery technology continues to mature, the field has yet to make headway for much more common complex diseases because of target risk. At Gordian, we leverage proven gene therapy delivery technology to screen thousands of targets for these diseases, eliminating this barrier.

Chris Towne VP, Preclinical Research and Gene Therapy
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II. Mosaic Screening

Pooled in vivo experiments

We create a pooled library of hundreds of therapies and test them in vivo in individual Patient Avatars.

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III. Pythia

AI-Powered Analysis

Instead of focusing on a single hypothesis for disease, Gordian’s Pythia examines the entire transcriptome to see how each of these therapies affects dozens of cellular pathways in the living animal.

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Learn more about our science

Recorded Gordian conference talks

Preprint on mosaic screening -  Multispecies, Modality-Agnostic Scalable In Vivo Mosaic Screening Platform for Therapeutic Target Discovery

Review paper covering the ins and outs of in vivo screening

Papers on disease biology

Opinion piece on why Gordian is using gene therapy to target age-related diseases

A detailed overview talk Martin gives on the science and landscape of aging biology